Synthetic tumor data helps AI improve long-read cancer mutation detection

A research team at The University of Hong Kong (HKU), has developed ClairS—a deep-learning algorithm that significantly ...

RNA testing uncovers 171 mutations driving MET exon 14 skipping in lung cancer

New research has shown that RNA-based testing can improve the detection and interpretation of clinically actionable genomic alterations that lead to MET exon 14 skipping in patients with lung ...
News-Medical.Net

RNA-based testing can improve detection of key lung cancer biomarkers

New research has shown that RNA-based testing can improve the detection and interpretation of clinically actionable genomic alterations leading to MET exon 14 skipping in lung cancer ...
News-Medical.Net

Optimizing 16S rRNA sequencing workflows

Microbiome sequencing has a reputation issue. From the outside, it appears to be one of modern biology's most powerful tools: ...
marktechpost

How to Build a Single-Cell RNA-seq Analysis Pipeline with Scanpy for PBMC Clustering, Annotation, and Trajectory Discovery

In this tutorial, we perform an advanced single-cell RNA-seq analysis workflow using Scanpy on the PBMC-3k benchmark dataset. We start by loading the dataset, inspecting its structure, and applying ...
marktechpost

A Coding Guide to Build a Complete Single Cell RNA Sequencing Analysis Pipeline Using Scanpy for Clustering Visualization and Cell Type Annotation

In this tutorial, we build a complete pipeline for single-cell RNA sequencing analysis using Scanpy. We start by installing the required libraries and loading the PBMC 3k dataset, then perform quality ...
GEN

Screening mRNA Therapeutics with Protein Barcoding

Nucleic acid-based therapeutics, including antisense oligonucleotides (ASO), small interfering RNA (siRNA), messenger RNA (mRNA), immunomodulatory DNA/RNA, and gene-editing guide RNA (gRNA), hold ...
ascopubs.org

Error Reduction in Leukemia Machine Learning Classification With Conformal Prediction

Assessing Algorithmic Fairness With a Multimodal Artificial Intelligence Model in Men of African and Non-African Origin on NRG Oncology Prostate Cancer Phase III Trials Recent advances in machine ...
eLife

Integrated Analysis of Single-Cell and Bulk RNA-Seq Data reveals that Ferroptosis-Related Genes Mediated the Tumor Microenvironment predicts Prognosis, and guides Drug ...

This study presents a useful finding for the ferroptosis-mediated tumor microenvironment (TME) in triple-negative breast cancer (TNBC) using public single-cell RNA sequencing (scRNA-seq) and bulk RNA ...
GitHub

CACIMAR: cross-species analysis of cell identities, markers and regulations using single-cell sequencing profiles

For users who want to perform cross-species analysis quickly, we provide a brief tutorial based on small single-cell RNA sequencing (scRNA-seq) data to demonstrate the functionality and API of CACIMAR ...
Europe PMC

Building and analyzing metacells in single-cell genomics data.

The advent of high-throughput single-cell genomics technologies has fundamentally transformed biological sciences. Currently, millions of cells from complex biological tissues can be phenotypically ...