During development, cells make sequential decisions to change their state, eventually generating the tremendous cellular diversity in our body. To describe this process, Conrad Waddington proposed ...

tascCODA posits a Dirichlet-Multinomial model for Y i,⋅ for each sample i ∈ 1…, n, thus accounting for the compositional nature of the count data. The covariates are associated with the features ...

With the recent explosion in the amount, the variety, and the dimensionality of available data, identifying, extracting, and exploiting their underlying structure has become a problem of fundamental ...

Normalization is essential for RNAseq analysis. However, one needs to understand the underlining assumptions for each methods. Most methods assume there is no global changes between conditions (e.g.

Spurred by advances in processing power, memory, storage, and an unprecedented wealth of data, computers are being asked to tackle increasingly complex learning tasks, often with astonishing success.

Most work on community detection does not address the issue of statistical significance, and many algorithms are prone to overfitting. We address this using tools from statistical physics. Rather than ...