Wastewater Digest

bioMérieux launches multiplex PCR test for wastewater pathogen monitoring

Mérieux introduces WATCHFIRE, a multiplex PCR wastewater testing system that detects over 40 pathogens within an hour, aiding ...
C&EN

The history of a monumental forensic tool and the ethical debate sparked by wrongful convictions based on trace DNA evidence

A warning to listeners — this episode contains sensitive material surrounding homicide and assault. On November 29th, 2012, a group of men broke into the Silicon Valley mansion of 66 year old investor ...
Frontiers

Allelic Dropout Is a Common Phenomenon That Reduces the Diagnostic Yield of PCR-Based Sequencing of Targeted Gene Panels

Primary cardiomyopathies (CMPs) are monogenic but multi-allelic disorders with dozens of genes involved in pathogenesis. The implementation of next-generation sequencing (NGS) approaches has resulted ...
Frontiers

Sanger Validation of High-Throughput Sequencing in Genetic Diagnosis: Still the Best Practice?

Next-generation sequencing (NGS)’s crucial role in supporting genetic diagnosis and personalized medicine leads to the definition of Guidelines for Diagnostic NGS by the European Society of Human ...
ahajournals.org

In Vivo AAV-CRISPR/Cas9–Mediated Gene Editing Ameliorates Atherosclerosis in Familial Hypercholesterolemia

Mutations in low-density lipoprotein (LDL) receptor (LDLR) are one of the main causes of familial hypercholesterolemia, which induces atherosclerosis and has a high lifetime risk of cardiovascular ...
The Lancet

Re-emergence of yaws after single mass azithromycin treatment followed by targeted treatment: a longitudinal study

dDepartment of Medicine, University of Washington, Seattle, WA, USA eDepartment of Global Health, University of Washington, Seattle, WA, USA ...
SciELO

PCR-RFLP assay as an option for primary HPV test

From November 2011 to March 2013, 990 women were attended for cervical screening in public clinics in São Miguel do Oeste, SC, Brazil. Three hundred and twenty-five of those women accepted to ...
Time

It Might Be Impossible to Get Away With Crime Some Day

Follow this section to personalize your feed and get instant alerts. WHY FOLLOW? Update your preferences in Account Settings Personalized Content Follow this tag to personalize your feed and get ...
C&EN

Long-Term Effects of Multiwalled Carbon Nanotubes and Graphene on Microbial Communities in Dry Soil

Little is known about the long-term effects of engineered carbonaceous nanomaterials (ECNMs) on soil microbial communities, especially when compared to possible effects of natural or industrial ...
Europe PMC

Standardisation and evaluation of a quantitative multiplex real-time PCR assay for the rapid identification of Streptococcus pneumoniae .

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ahajournals.org

CRISPR-Cas9 Genome Editing of a Single Regulatory Element Nearly Abolishes Target Gene Expression in Mice—Brief Report

To ascertain the importance of a single regulatory element in the control of Cnn1 expression using CRISPR/Cas9 (clustered regularly interspaced short palindromic repeats/CRISPR-associated protein 9) ...