This important study provides a mechanistic view of how antibody affinity maturation can reshape encounter-state landscapes and association pathways, with implications for understanding HIV antibody ...

In all patients, results of a platelet factor 4 (PF4)–induced platelet-activation (PIPA) assay were strongly positive, and serum from all the patients tested strongly positive against PF4 alone in a ...

Auxin response evolved nearly half a billion years ago in the earliest land plants. Auxin response is mediated by a family of DNA-binding ARF transcription factors. It has been unclear if and how the ...

To ensure successful usage of our tool, please make sure you have added the FoldX executable to your environment. Additionally, for cartesian_ddg calculations in slow mode, or ddg_monomer row1 ...

We describe the case of identical twin boys who presented with low body weight despite excessive caloric intake. An evaluation of their fibroblasts showed elevated oxygen consumption and decreased ...

A feline panleukopenia virus (FPV), Giant panda/CD/2018, was isolated from a captive giant panda with mild diarrhea in 2018 in Chengdu, China, and further identified via indirect immunofluorescence ...

The large number of pathologies that position CCR5 as a central molecular determinant substantiates the studies aimed at understanding receptor-ligand interactions, as well as the development of ...

Department of Internal Medicine III, Cardiology and Angiology, University Medical Center Schleswig-Holstein, Campus Kiel (D.F., A.Y.R., A. Bernt, A. Borlepawar, P.U ...

*A short script to do high-throughput mutagenesis using the PyMOL API in Python. *Download the example file 'ClassA_v2r_human_Inactive_4BUO_2019-03-14_GPCRDB_B.pdb' and 'AlanineMutagenesis.py' to run ...

ABSTRACT: Chitosanases EAG1, a classical glycoside hydrolase from Bacillus ehimensis, is relatively unstable with higher temperature. This shortcoming seriously restricts its industrial application.