Metabolic reprogramming has emerged as a hallmark of numerous pathological conditions, including chronic inflammatory disorders, metabolic diseases, and ...

Head and neck cancer remains a major global health challenge, ranking among the six most common cancers worldwide and claiming hundreds of thousands of lives each year. A growing body of evidence now ...

Solid tumors often provide a challenging environment for the T cells of our immune system. By reprogramming the metabolism of T cells, scientists at the VIB-KU Leuven Center for Cancer Biology and ...

Why do some of the most advanced cancer therapies fail against solid tumors? Despite remarkable success in blood cancers, CAR-T cell treatment is much less effective against solid tumors due to the ...

Bile acid metabolism suppression was linked to colorectal cancer prognosis and a 15 gene signature predicted overall survival ...

Aerobic glycolysis dominates lesion bioenergetics, with lactate promoting histone lactylation, M2 macrophage polarization, CD8⁺ T-cell exhaustion, EMT, and fibrosis that reinforce immune-protected ...

A single preoperative blood sample may help improve the prediction of recurrence or metastasis in patients with colorectal ...

Senescence, aging, and age-related diseases represent complex biological phenomena with significant impacts on human health, and metabolism and metabolomics play pivotal roles in understanding their ...

Leuven, 11 March 2025 – Solid tumors often provide a challenging environment for the T cells of our immune system. By reprogramming the metabolism of T cells, scientists at the VIB-KU Leuven Center ...