A newly mapped step in DNA replication suggests that strand separation begins at a precise junction between two helicase ...

For decades, scientists have largely relied on painstaking trial and error to coax proteins into crystalline forms.

This guide brings together practical recommendations and workflow considerations to reduce unnecessary troubleshooting and ...

We are living in an era where biology has become synonymous with big data due to the ever-increasing amount of data being generated by technologies such as next-generation sequencing. Bioinformatics ...

This valuable study identifies and characterizes probe binding errors in a widely used commercial platform for visualizing gene activity in tissue samples, discovering that at least 21 out of 280 ...

Article subjects are automatically applied from the ACS Subject Taxonomy and describe the scientific concepts and themes of the article. The sequence-based approach primarily relies on amino acid ...

One metric for evaluating the quality of a transcriptome assembly is to examine the number of transcripts that were assembled that appear to be full-length or nearly full-length. Such an analysis with ...

dNational Institute for Health Research Nottingham Biomedical Research Centre, Nottingham University Hospitals National Health Service Trust, Nottingham, United Kingdom eWolfson Centre for Global ...

In the field of genome assembly, contig assembly is one of the most important parts. Contig assembly requires the processing of overlapping regions of a large number of DNA sequences and this ...

CRISPR-Cas13 mediates robust transcript knockdown in human cells through direct RNA targeting.1, 2, 3, 4 Compared with DNA-targeting CRISPR enzymes like Cas9, RNA ...