Just like us, bacteria are under constant threat of infection by viruses (called phages). We’ve found that many bacteria are armed with sophisticated viral defence systems powered by reverse ...

New research has determined the spatial structure of various processes of a novel gene-editing tool called 'prime editor.' Functional analysis based on these structures also revealed how a 'prime ...

The findings were published in the journal Nature ("Structural basis for pegRNA-guided reverse transcription by the prime editor"). Overall structure of the prime editor complex. (Image: The ...

Surface model of SpCas9–reverse transcriptase–pegRNA–target DNA complex. The prime editor, composed of a SpCas9 and a reverse transcriptase, reverse transcribes template sequence in pegRNA, resulting ...