The importance of the extracellular matrix (ECM) to pancreatic islets has been clearly demonstrated, as isolated islets grown in culture or transplanted, quickly lose viability and function after ...

Phosphorylation is essential for the regulation of the development of plant seedlings, while the kinases responsible for photomorphogenic hypocotyl elongation are largely unknown. Here, we reveal that ...

In humans, 103 ECM components, including 14 collagens, 35 noncollagen glycoproteins, and 10 proteoglycans, were identified via proteomic analysis of the ascending aortas, 6 whereas >150 ECM- or ...

Aging is defined as the functional decline of tissues and organisms, leading to many human conditions, such as cancer, neurodegenerative diseases, and hair loss. Although stem cell exhaustion is ...

Cardiac fibrosis plays a critical role in the pathogenesis of heart failure. Excessive accumulation of extracellular matrix (ECM) resulting from cardiac fibrosis impairs cardiac contractile function ...

We have investigated how the directed cell migration toward stiffer extracellular matrix (ECM) is guided by filopodial mechanosensing of the surrounding ECM stiffness. As filopodia bind to the ...