This important study provides a mechanistic view of how antibody affinity maturation can reshape encounter-state landscapes and association pathways, with implications for understanding HIV antibody ...

A 3D plastic model of a carbon dioxide molecule. Strategies for using carbon dioxide in synthesis usually focus on the carbon atom. Now researchers are thinking about how to put its two oxygens to use ...

Cations are ions that are positively charged. Anions are ions that are negatively charged. Ions are charged atoms or molecules. If a balanced atom loses one or more electrons, it will become a ...

Affinity and avidity are two terms used in immunology and microbiology to describe binding strength between an antibody and antigen. Because both affinity and avidity involve binding strength, the two ...

Protein-protein interactions govern a wide range of biological activity. A proper estimation of the protein-protein binding affinity is vital to design proteins with high specificity and binding ...

Researchers in Japan have made perfluorocubane for the first time. When reduced, the molecule can hold a single electron inside its box-like structure – an unusual, real-life example of the quantum ...

The virus-based immunosorbent nanoparticle is a nascent technology being developed to serve as a simple and efficacious agent in biosensing and therapeutic antibody purification. There has been ...

Contributed by David A. Agard, July 2, 2020 (sent for review May 16, 2020; reviewed by John L. Rubinstein and Hongwei Wang) Despite the increasing efforts in developing affinity grids to facilitate ...

Here, we hypothesized that multimeric forms of VEGF and PlGF may affect sFlt-1 affinity by steric effects and altered accessibility of the VEGF/sFlt-1 interface yielding enhanced sFlt-1 capturing ...