A lot of effort has gone into finding ways to minimize or eliminate off-target edits. In a recent issue of Nature, ...

All cellular life-from humans to bacteria-possesses two layers of immunity: innate and adaptive. Scientists have long ...

CFG offers massively parallel genetic perturbations and genetic screening for unbiased discovery. Examples of our toolbox include genome-wide or custom CRISPR-based loss- and gain-of-function screens, ...

Article subjects are automatically applied from the ACS Subject Taxonomy and describe the scientific concepts and themes of the article. Sensitivity data and the chemical structure of each monoterpene ...

Lung cancer is an extremely aggressive and highly prevalent disease worldwide, and it is one of the leading causes of cancer death. Deciphering intrinsic genetic mechanism, finding new targets, and ...

Lentiviral (LV) vectors have emerged as powerful tools for treating genetic and acquired human diseases. As clinical studies and commercial demands have progressed, there has been a growing need for ...

Department of Pharmaceutical Chemistry, University of Kansas, Lawrence, Kansas 66047, United States Article Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both ...

In this work, we developed an imaging-based pooled-library CRISPR screening approach that provides readouts of both phenotype and genotype of individual cells by high-resolution, high-content imaging.

CRISPR-based genetic screens are accelerating biological discovery, but current methods have inherent limitations. Widely used pooled screens are restricted to simple readouts including cell ...

CRISPRAnalyzeR is now available for download - see below or check out the wiki. You can use the provided CRISPRAnalyzeR web-service or download the suite for ...