The mean (SD) follow-up time among men who were free of CHD at baseline (n = 1958) was 21.4 (10.4) years, and 717 (37%) of them had the disease and 301 (15%) died for CHD before the end of follow-up.
Objectives Although both physical inactivity and poor sleep are deleteriously associated with mortality, the joint effects of these two behaviours remain unknown. This study aimed to investigate the ...
aDepartment of Environmental Health, Harvard TH Chan School of Public Health, Boston, MA, USA bDepartment of Biostatistics, Harvard TH Chan School of Public Health, Boston, MA, USA cDepartment of ...
Concomitant use of multiple drugs for therapeutic purposes is known as “polypharmacy situations,” which has been recognized as an important social problem recently. In polypharmacy situations, each ...
The major histocompatibility complex (MHC), in particular, the human leukocyte antigen (HLA) loci encode key components of the immune system and include some of the most diverse genes in the human ...
Risk prediction models can translate genetic association findings for clinical decision-making. Most models are evaluated on their ability to discriminate, and the calibration of risk-prediction ...
Pairwise models are commonly used to describe many-species communities. In these models, an individual receives additive fitness effects from pairwise interactions with each species in the community ( ...
Sometimes mutations in two genes produce a phenotype that is surprising in light of each mutation's individual effects. This phenomenon, which defines genetic interaction, can reveal functional ...
Background and Purpose— Numerous effective strategies for the secondary prevention of cardiovascular events in high-risk patients have now been established. We sought to calculate the cumulative ...
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