In 2020, the world watched anxiously as scientists scrambled to develop defences against COVID-19. Faced with a new, deadly infectious disease, immunologists worked day and night to develop vaccines ...

This article explores how advances in AI, structural biology, and new drug modalities are transforming “undruggable” proteins into viable targets, opening new paths for treating cancer, ...

Researchers in Korea have developed a new near-infrared (NIR) fluorescent dye with significantly improved photostability, overcoming the rapid signal fading that has long limited fluorescence imaging ...

Congestive heart failure is when the heart can’t pump enough blood for the body’s needs. Common symptoms include fatigue, leg swelling, and shortness of breath. Treatment may include diet changes, ...

Researchers at the University of Twente have developed an optical method that follows the shape changes of a single protein ...

Malignant melanoma is one of the most dangerous forms of cancer. Around half of melanomas and about 7% of all other cancers ...

The enzyme tRNA-guanine transglycosylase (TGT) chemically modifies transfer RNA (tRNA) and plays a key role in how ...

A lot of effort has gone into finding ways to minimize or eliminate off-target edits. In a recent issue of Nature, ...

Proteins carry out most of the work in the cell, and predicting their structure, function and interactions remains one of the ...

OverviewProteins are not static molecular objects but dynamic conformational ensembles whose structures, motions, disorder, ...

BACKGROUND: Metabolic adaptation and maladaptation are hallmarks of the failing heart and may be a target for therapeutic ...

In this useful Tools & Resources article, the authors describe a new cryogenic light microscopy design and characterize its temperature and spatial stability. This compelling system avoids the ...