A complete and modification-aware version of the DAVIS dataset by incorporating 4,032 kinase–ligand pairs involving substitutions, insertions, deletions, and phosphorylation events. The DAVIS-complete ...

Researchers at Rensselaer Polytechnic Institute (RPI) have found that today's leading artificial intelligence tools for ...

Malignant melanoma is one of the most dangerous forms of cancer. Around half of melanomas and about 7% of all other cancers ...

Poxviruses have a long history in human disease as well as medicine: The first-ever vaccine was developed to protect against ...

GOOSE produces blueprints for custom-built disordered proteins that are then created in genetically engineered cells.

Current therapies for Parkinson’s disease and related conditions primarily treat symptoms but don’t stop the underlying process causing the disease. Increasing evidence suggests that toxic clumps of ...

A shrunk version of hemoglobin, left, compared to the reference hemoglobin. Credit: Rohit Singh A new AI-based program, dubbed Raygun, can suggest strategic cuts to a protein’s amino acid sequence to ...

This important study provides a mechanistic view of how antibody affinity maturation can reshape encounter-state landscapes and association pathways, with implications for understanding HIV antibody ...

Seq2Pocket is a framework for protein ligand binding site (LBS) prediction that maps sequence-level predictions to 3D structural pockets. The method utilizes finetuned protein language model (pLM) to ...

Department of Physics, University of Guelph, 50 Stone Rd. E., Guelph, Ontario N1G 2W1, Canada ...