Glutamate receptors, including AMPA and NMDA subtypes, are pivotal mediators of excitatory transmission and plasticity across the mammalian central nervous system. Their regulation, which involves ...

Surprising findings published in PNAS have implications for understanding and treating neurological and neuropsychiatric disorders.

When it comes to brain proteins, small changes can make a dramatic difference. Researchers studying NMDA (N-methyl-D-aspartate) receptors, which are essential for learning, memory and moment-by-moment ...

Scientists have revealed the molecular structure of a type of receptor that's crucial to brain development and function. 'This study shows the dominant assemblies and states of the GABA receptor. That ...

The Sanz-Clemente Lab is devoted to identifying molecular mechanisms regulating glutamate receptor subsynaptic location and utilizing this knowledge to revert/prevent alterations associated with ...

Drugs that act on NMDA (N-methyl-D-aspartate) receptors, which are essential for learning, memory and moment-by-moment consciousness, are key for treating neuropsychiatric disorders. These drugs were ...

Northwestern University researchers have identified structural features in engineered cell receptors that correlate with ...

Neurons generated from stem cells (from skin fibroblasts) of a patient with sporadic Alzheimer’s disease. Visualized with a specific green fluorescent marker. Nuclei are shown in blue. Researchers ...

The FDA approved combination dextromethorphan and bupropion extended-release tablets (Auvelity) for adults with major depressive disorder (MDD), Axsome Therapeutics announced on Friday.

Scientists have revealed the molecular structure of a type of receptor that’s crucial to brain development and function. Known as Type A GABA receptors, these receptors are already targeted by ...