ESMs, a proteome-scale framework to classify loss-of-function missense variants into distinct mechanistic groups by combining two complementary state-of-the-art machine learning models. The strength ...

Natural selection uses duplicated genes as raw material for functional innovation, co-opting their existing features to new functions. Understanding genetic innovation requires two questions to be ...

'Inheritance through homology' is the most common and generally more accessible approach to function prediction, but orthology should be established where possible to improve confidence in predictions ...

Sen. Shawn Gumataotao seeks to abolish the Guam Office of Civil Defense and transfer emergency preparedness and response functions to a bureau under the Guam Fire Department, citing the need for ...

Objects can have a calculate function defined on them to allow them to react to different events happening in the game. The main time for this to happen is during scoring, but there are other contexts ...

In this important work, the authors present a new transformer-based neural network designed to isolate and quantify higher-order epistasis in protein sequences. They provide solid evidence that higher ...

Card objects can be given permanent permanent bonuses that allow them to add or subtract score, similar to the vanilla Hiker joker. These are only considered on playing cards during the scoring phases ...