A new genetic tool helps researchers uncover the logic of gene regulation

The human genome contains more than 20,000 genes. However, at any given time and in a given cell, only a fraction are active.
PNAS

Orthogonal disentanglement of single-cell multi-omics reveals private and shared drivers of tissue development and pathogenesis

Tissues develop and diseases progress through coordinated changes in gene expression and gene regulation, which can now be measured by single-cell multi-omics. However, these datasets contain both ...
marktechpost

A Coding Guide to Build a Complete Single Cell RNA Sequencing Analysis Pipeline Using Scanpy for Clustering Visualization and Cell Type Annotation

In this tutorial, we build a complete pipeline for single-cell RNA sequencing analysis using Scanpy. We start by installing the required libraries and loading the PBMC 3k dataset, then perform quality ...
eLife

Ribosome demand links transcriptional bursts to protein expression noise

This study focuses on a previously reported positive correlation between translational efficiency and protein noise. Using mathematical modeling and analysis of experimental data the authors reach the ...
GEN

The Cross-Species Cell Atlas: Chan Zuckerberg Initiative Releases TranscriptFormer AI Model

“Hey model, if I prompt you with the marker genes for a cell type, can you complete the transcription factors that you believe would be highly expressed with expression of these genes?” posed ...
Frontiers

Rvisdiff: An R package for interactive visualization of differential expression

Rvisdiff is an R/Bioconductor package that generates an interactive interface for the interpretation of differential expression results. It creates a local web page that enables the exploration of ...
The Lancet

The complex genetic architecture of Alzheimer's disease: novel insights and future directions

Copyright: © 2023 The Author(s). Published by Elsevier B.V. Two new AD/dementia GWAS have dramatically expanded the sample sizes and the number of disease ...
C&EN

Navigating Transcriptomic Connectivity Mapping Workflows to Link Chemicals with Bioactivities

Get article recommendations from ACS based on references in your Mendeley library. Pair your accounts. Export articles to Mendeley Get article recommendations from ACS based on references in your ...
Frontiers

IOBR: Multi-Omics Immuno-Oncology Biological Research to Decode Tumor Microenvironment and Signatures

Recent advances in next-generation sequencing (NGS) technologies have triggered the rapid accumulation of publicly available multi-omics datasets. The application of integrated omics to explore robust ...
IEEE

Dynamic Bayesian Network Learning to Infer Sparse Models From Time Series Gene Expression Data

Abstract: One of the key challenges in systems biology is to derive gene regulatory networks (GRNs) from complex high-dimensional sparse data. Bayesian networks (BNs) and dynamic Bayesian networks ...
GitHub

SpaGCN: Integrating gene expression, spatial location and histology to identify spatial domains and spatially variable genes by graph convolutional network

Jian Hu*, Xiangjie Li, Kyle Coleman, Amelia Schroeder, Nan Ma, David J. Irwin, Edward B. Lee, Russell T. Shinohara, Mingyao Li* SpaGCN is a graph convolutional network to integrate gene expression and ...