Jun Yang and colleagues perform targeted sequencing of NUDT15 and identify loss-of-function variants associated with thiopurine intolerance. Functionally, they show that NUDT15 inactivates thiopurine ...

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Human-derived organoids improved heart function in pigs with ischemic heart disease, laying the groundwork for their therapeutic potential in humans.

MSN via Barron Kerry Stewart, an exercise physiologist and professor of medicine at Johns Hopkins, says exercise capacity "definitely declines" as we age. "With regular exercise, the decline won't be ...