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Cilia dysfunction, including impaired intraflagellar transport (IFT), underlies ciliopathies like Joubert syndrome. In Caenorhabditis elegans, kinesin-II and OSM-3 drive IFT in the middle ciliary ...
Nephronophthisis (NPH) is an autosomal recessive kidney disease that accounts for up to 15% of end-stage renal disease (ESRD) in children (Hamiwka et al., 2008; Salomon et al., 2009). In addition, ...
Department of Biological Sciences, College of Science, King Faisal University, Al-Ahsa 31982, Saudi Arabia ...
Cilia, which either generate coordinated motion or sense environmental cues and transmit corresponding signals to the cell body, are highly conserved hair-like structures that protrude from the cell ...
Figure 1. Cardiogenesis in mice. AV indicates atrioventricular; DA, ductus arteriosus; E, embryonic day; IFT, inflow tract; LA, left atrium; LV, left ventricle; OFT ...
Endothelial cells (ECs) sense and respond to flow-induced mechanical stress, in part, via microtubule-based projections called primary cilia. However, many critical steps during vascular morphogenesis ...
Cilia dysfunction underlies a class of human diseases with variable penetrance in different organ systems. Across eukaryotes, intraflagellar transport (IFT) facilitates cilia biogenesis and cargo ...
Primary cilia are evolutionarily conserved cellular organelles that organize diverse signalling pathways. Defects in the formation or function of primary cilia are associated with a spectrum of human ...
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