Additionally, the researchers analyzed the expression of NFκB and KLF2 and the effects of IL-1β on endothelial cells to understand the relationship between PAI-1 polymorphisms and COVID-19 severity.

Effects of Genetic Polymorphisms on the Pharmacokinetics of Calcineurin Inhibitors Kyle N. Utecht; Jon J. Hiles; Jill Kolesar Disclosures Am J Health Syst Pharm. 2006;63 (23):2340-2348. 0 ...

Clopidogrel is a prodrug that requires biotransformation to an active metabolite by cytochrome P-450 (CYP) enzymes (Figure 1 in the Supplementary Appendix, available with the full text of this ...

The anti–HER-2/ neu monoclonal antibody trastuzumab has been shown to engage both activatory (fragment C receptor [FcγR]IIIa; FcγRIIa) and inhibitory (FcγRIIb) antibody receptors and FcγR ...

This review presents the latest evidence on the link between genetic single nucleotide polymorphisms and dental caries, ...

The studies revealed that polymorphisms were associated with susceptibility to periodontal diseases. In other word, genetic variations can change the development of CP.

Background: Genetic polymorphisms in DNA repair genes may influence individual variation in DNA repair capacity and may play an important role in carcinogenesis. We investigated the role of genetic ...

Single nucleotide polymorphisms (SNPs) are variations in a genome’s base pair in a DNA sequence, and occur in approximately 1 out of 800 base pairs. These occur when a single nucleotide is ...

The researchers found that the CYP2C19*1 and CYP2C19*17 allele frequencies were 71.0 and 18.0 percent, respectively, for the healthy group and 81.1 and 18.9 percent, respectively, for the patient ...

On the other hand, mimicry has diversified at every taxonomic level; warning color has evolved from cryptic patterns, and there are mimetic polymorphisms within species, multiple color patterns in ...