Immediate-early genes (IEGs), including c-Fos, are integral to the brain's response to stimuli. Initially identified as a proto-oncogene, c-Fos is essential for neural activity, synaptic ...

c-Fos proto-oncoprotein is a short-lived transcription factor degraded by the proteasome in vivo. Its mutated forms expressed by the mouse osteosarcomatogenic retroviruses, FBJ-MSV and FBR-MSV ...

Protein kinase C (PKC) activity was measured using liquid scintillation counting. Puerarin (10−5 mmol/L) significantly ameliorated the high-glucose effect on c-fos, c-jun and CoIV expression.