For most people, swallowing is second nature, but how does it occur, and why do some people have difficulty with it? Researchers at Kyushu University in Japan have started to tackle these questions by ...

Calcium ions orchestrate contraction and relaxation in airway smooth muscle by regulating excitation–contraction coupling. In quiescent cells, basal cytosolic Ca2+ is maintained at nanomolar levels by ...

Ferulic acid suppresses ileal smooth muscle contraction by inhibiting calcium ion influx through voltage-dependent calcium channels. This action may help prevent or treat excessive intestinal motility ...

Because RyR1 is also expressed in neurons, immune cells, and vascular smooth muscle, the E3896A model offers a unique tool to examine CICR's broader physiological roles. By combining gene engineering, ...

The mechanism of skeletal muscle contraction is a process that relies on calcium signaling. However, the physiological role of calcium-induced calcium release (CICR) through the ryanodine receptor ...