In the mammalian brain, synaptic transmission usually depends on presynaptic action potentials (APs) in an all-or-none (or digital) manner. Recent studies suggest, however, that subthreshold ...

Also referred to as chemical messengers, neurotransmitters are chemical agents made and released by neurons. They are stored in vesicles at the terminal end (presynaptic terminal) of a neuron ...

Presynaptic Mitochondria Volume and Abundance Increase during Development of a High-Fidelity Synapse. The Journal of Neuroscience, 2019; 39 (41): 7994 DOI: 10.1523/JNEUROSCI.0363-19.2019 ...

Presynaptic Plasticity Brad FitzpatrickA group of slow-witted, mutant mice and a protein called RIM1α may provide insight into learning and memory mechanisms. University of Texas Southwestern ...

Dysfunction of the prefrontal cortex in schizophrenia may be associated with abnormalities in synaptic structure and/or function and reflected in altered concentrations of proteins in presynaptic ...

The phosphoprotein interacted with presynaptic vesicle trafficking and recycling proteins. All told, the Roy and Dettmer labs found that phosphorylation of α-synuclein drives synaptic protein-protein ...

Re-uptake – the neurotransmitter is reabsorbed back into the presynaptic neuron and restored inside a vesicle ready to be used again. For example, noradrenaline.

SSRIs may take around two to four weeks to raise the levels of serotonin in the brain and the treatment benefits may not be seen for a month or so. Once serotonin levels are raised however, mood ...

In the current study, the Mandelkows used these mice to investigate the presynaptic effects of tau aggregates. Presynapses are generally harder to study than postsynapses because they are harder to ...

Daniel M. Michaelson, Sofia Avissar, Yoel Kloog, Mordechai Sokolovsky, Mechanism of Acetylcholine Release: Possible Involvement of Presynaptic Muscarinic Receptors in Regulation of Acetylcholine ...