The promyelocytic leukemia (PML) tumor suppressor is essential for the formation of PML nuclear bodies (NBs). PML and PML-NBs have been implicated in the regulation of growth inhibition, senescence ...
Figure 1: Pml-/-mice have accelerated revascularization in response to ischaemia. Figure 2: Pml controls Hif-1α activity and accumulation rate in hypoxic conditions. To exclude further that PML ...
A differential blood count revealed grade 3 lymphocytopenia (Figure 1, and Tables S1 and S2 in the Supplementary Appendix). Retrospective analysis revealed that the lymphocytopenia had reached grade 3 ...
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