We propose a two-step estimating procedure for generalized additive partially linear models with clustered data using estimating equations. Our proposed method applies to the case that the number of ...

Cancer is viewed as a multistep process whereby a normal cell is transformed into a cancer cell through the acquisition of mutations. We reduce the complexities of cancer progression to a simple set ...

We consider a model for Darwinian evolution in an asexual population with a large but nonconstant populations size characterized by a natural birth rate, a logistic death rate modeling competition and ...

Complex traits with multiple phenotypic values changing over time are called time-dependent or longitudinal traits. Knowledge of the genetic effects influencing longitudinal patterns is important to ...