For researchers on the hunt for the genetic roots of disease, the cost of deep whole-genome sequencing makes it challenging ...

Phylo-Plex, a new computational method, has been developed by Wellcome Sanger Institute scientists and their collaborators to allow cost-effective and scalable DNA sequencing of pathogens in ...

A team from the Andalusian Center for Molecular Biology and Regenerative Medicine (CABIMER) has developed an innovative technique called PLAMseq (proximity-labeled affinity-purified mass spectrometry ...

Cornell researchers have found that a new DNA sequencing technology can be used to study how transposons move within and bind to the genome. Transposons play critical roles in immune response, ...

In a way, sequencing DNA is very simple: There's a molecule, you look at it, and you write down what you find. You'd think it would be easy—and, for any one letter in the sequence, it is. The problem ...

Researchers benchmarked nanopore methylation callers across bacterial, plant, mouse, and human datasets, comparing accuracy, ...

Traditional bisulfite sequencing damages DNA, while enzyme-based alternatives are inconsistent. A novel methylation analysis method, called UMBS-seq, has been published in Nature Communications.

In 1995, with the Human Genome Project underway, sequencing was all the rage. Scientists working on the project cloned short fragments of the whole genome and used Sanger sequencing to determine the ...

Definition: DNA amplification is the laboratory process of making many copies of a selected DNA sequence from a very small starting amount. It allows DNA that would otherwise be too scarce to detect ...