RNA-based therapeutics are transforming medicine, but scaling production efficiently remains a challenge, particularly the ...

The Rocky Mountain Journal of Mathematics, Vol. 38, No. 5, Special Issue: Proceedings of the 4th International Conference on Mathematical Biology (2008), pp. 1377-1384 (8 pages) In this study, the ...

While industrial bioprocesses have been operated in fed-batch mode for a long time, the screening of high-producer cell lines and a lot of other development work is still performed in batch mode for a ...

A conventional production fed-batch process involves a multi-stage seed expansion and elaborate clarification steps to isolate the protein of interest from other process impurities. The current ...

Figure 1: Concept of the systems metabolic engineering framework. Figure 3: General scheme of systems metabolic engineering and its case study on the overproduction of 1,4-butanediol using E. coli 11.

The utilization of online process analytical technology (PAT) has become a high-profile endeavor in the biotechnology industry in recent years. Since the early 1980s, many fermentation scientists have ...

The biopharmaceutical industry has seen substantial growth in recent years, generating novel biotherapeutics and biosimilars at an unprecedented rate. One of the biggest challenges in the industry is ...