Medscape

Defining the COX Inhibitor Selectivity of NSAIDs: Implications for Understanding Toxicity

BAE: Bovine aortic endothelial; RHP: Recombinant human protein. NSAIDs variably inhibit prostaglandin H synthase (COX). COX-2 was cloned in 1991, and it was subsequently established that COX-1 does ...
Medicine Buffalo

Identification of the Molecular Determinants Delineating Functional Behavior in COX-1 Versus COX-2

This project is not being offered for the current term. Please check back next semester for updates. The cyclooxygenase enzymes (COX-1 and COX-2) catalyze the committed step in the biosynthesis of ...
The Scientist

COX-2 and renal function

NEW YORK, July 18 (Praxis Press) A new class of nonsteroidal anti-inflammatory drugs selectively inhibits cyclooxygenase (COX)-2 and may produce fewer adverse effects than nonselective inhibitors.

Aleve vs. Advil - What's the difference? Comparing these NSAIDs

SaveHealth reports that Aleve and Advil are popular NSAIDs for pain relief, differing in duration, dosing, and safety ...
Medscape

Efficacy and Tolerability of Meloxicam, a COX-2 Preferential Nonsteroidal Anti-Inflammatory Drug

The pharmacodynamic properties of meloxicam have been reviewed by various authors, including Noble & Balfour. [16] In this article, we focus on the main studies that have evaluated the affinity of ...
BioWorld

COX-2 inhibitor AAT-076 ameliorates neuropathic pain

AAT-076 was tested in the preclinical setting for its analgesic potential in COX-1 and COX-2 assays, as well as in in vivo rat models of air pouch inflammation, adjuvant-induced arthritis and ...